| Date | Transaction |
| 02-28-2122 | Jessie Lyle has retired from football. |
| 08-18-2120 | The St. Louis Cardinals have waived Jessie Lyle. |
| 09-25-2119 | The St. Louis Cardinals have moved Jessie Lyle to the active roster. The St. Louis Cardinals have moved Lyneal Foggie to the inactive roster. |
| 09-25-2119 | The St. Louis Cardinals have acquired Jessie Lyle from the waiver wire. |
| 09-19-2118 | The St. Louis Cardinals have waived Jessie Lyle. |
| 09-12-2118 | The St. Louis Cardinals have moved Jessie Lyle to the active roster. The St. Louis Cardinals have moved Troy Laaveg to the inactive roster. |
| 09-04-2118 | The St. Louis Cardinals have moved Corl Bransletter to the active roster. The St. Louis Cardinals have moved Jessie Lyle to the inactive roster. |
| 09-04-2118 | Jessie Lyle of the St. Louis Cardinals is injured with a groin pull and is expected to be out for approximately 7 days. |
| 09-06-2117 | The St. Louis Cardinals have moved Frank Wages, Cal Fralic, and Jessie Lyle to the active roster. The St. Louis Cardinals have moved Pete Silvestri and Jim Pyles to the inactive roster. |
| 05-02-2117 | The St. Louis Cardinals have moved Fred Roach to the active roster. The St. Louis Cardinals have moved Vic Rapacz and Jessie Lyle to the inactive roster. |
| 12-07-2116 | The St. Louis Cardinals have placed Jessie Lyle on the Injured Reserve list for the remainder of the season. |
| 12-06-2116 | Jessie Lyle of the St. Louis Cardinals is injured with a shoulder joint injury and is expected to be out for approximately 35 days. |
| 09-07-2116 | The St. Louis Cardinals have moved Frank Wages and Jessie Lyle to the active roster. The St. Louis Cardinals have moved Pete Silvestri to the inactive roster. |
| 05-03-2116 | The St. Louis Cardinals have moved Glen Geddes to the active roster. The St. Louis Cardinals have moved Jessie Lyle to the inactive roster. |
| 09-02-2115 | The St. Louis Cardinals have moved Frank Wages, Jessie Lyle, Terrelle Glenn, Billy Szafaryn, and Chuck Bush to the active roster. The St. Louis Cardinals have moved Everson Diehl, Cal Fralic, Karl Braatz, Brad Mitchell, and Randy Haynes to the inactive roster. |
| 04-28-2115 | The St. Louis Cardinals have moved Brad Mitchell to the active roster. The St. Louis Cardinals have moved Jessie Lyle to the inactive roster. |
| 09-03-2114 | The St. Louis Cardinals have moved Pete Roper, Frank Wages, Red Rohrig, Jessie Lyle, and Russ Harlow to the active roster. The St. Louis Cardinals have moved Jim Office, Harry Avedisian, Riley Sneddon, Glen Geddes, and Bob White to the inactive roster. |
| 01-01-2114 | The St. Louis Cardinals have moved Ray Hoak, Frank Wages, Jerry Lewis, Glen Geddes, and Allie Johnson to the active roster. The St. Louis Cardinals have moved Pete Roper, Carl Gwinn, Jessie Lyle, Jack Yezerski, and Chuck Bush to the inactive roster. |
| 09-04-2113 | The St. Louis Cardinals have moved Red Rohrig, Pete Roper, Carl Gwinn, Walt Reaves, and Jessie Lyle to the active roster. The St. Louis Cardinals have moved Allie Johnson, Ron Robustelli, Jim Wilbur, Doc Skoglund, and Mark McAdoo to the inactive roster. |
| 04-30-2113 | The St. Louis Cardinals have moved Ron Robustelli to the active roster. The St. Louis Cardinals have moved Jessie Lyle and Joe Smith to the inactive roster. |
| 09-05-2112 | The St. Louis Cardinals have moved Jessie Lyle and Jon Smoot to the active roster. The St. Louis Cardinals have moved Ron Robustelli to the inactive roster. |
| 05-01-2112 | The St. Louis Cardinals have moved Russ Harlow to the active roster. The St. Louis Cardinals have moved Jessie Lyle to the inactive roster. |
| 09-21-2111 | The St. Louis Cardinals have moved Jessie Lyle to the active roster. The St. Louis Cardinals have moved Ron Robustelli to the inactive roster. |
| 09-21-2111 | The St. Louis Cardinals have acquired Jessie Lyle from the waiver wire. |
| 09-13-2111 | The Anaheim Pinky Swear have waived Jessie Lyle. |
| 09-13-2111 | The Anaheim Pinky Swear have acquired Jessie Lyle from the waiver wire. |
| 09-13-2111 | The Anaheim Pinky Swear have automatically waived Jessie Lyle to comply with the 53-man roster limit. |
| 09-07-2111 | The Anaheim Pinky Swear have acquired Jessie Lyle from the waiver wire. |
| 09-07-2111 | The Anaheim Pinky Swear have moved Refrigerator Reeves to the active roster. The Anaheim Pinky Swear have moved Roland Jordan to the inactive roster. |
| 09-07-2111 | The Anaheim Pinky Swear have waived Jessie Lyle. |
| 09-21-2110 | The Anaheim Pinky Swear have moved Dennis Guffey to the active roster. The Anaheim Pinky Swear have moved Jessie Lyle to the inactive roster. |
| 09-21-2110 | The Anaheim Pinky Swear have moved Jessie Lyle to the active roster. The Anaheim Pinky Swear have moved Tom Holcomb to the inactive roster. |
| 12-09-2109 | The Anaheim Pinky Swear have moved Robert Walton to the active roster. The Anaheim Pinky Swear have moved Jessie Lyle to the inactive roster. |
| 08-14-2107 | The Anaheim Pinky Swear have moved Jessie Lyle to the active roster. The Anaheim Pinky Swear have moved Ron Robustelli to the inactive roster. |
Tight End